I use CSOS with Mckesson and love it! My director handled contacting the DEA and we had some paperwork to fill out but it's totally worth it. Plus my McKesson rep was a big help. I've been using it for over a year and hope I never have to go back to the 222 form.
Sorry I couldn't answer more about the set up part but I wanted to put my 2 cents in about CSOS. It rocks!!!